This page is intended to give patients a summary overview of the topic. Reading this page does not replace a medical consultation or a discussion with your doctor.
Pap III means that the test findings are unclear or inconclusive. Although the cells are clearly abnormal and altered, the cause of this can only be determined through further examination. In this case, the Pap smear is usually repeated after a certain period of time. At this stage, the affected cells have not yet developed into cancer cells.
With Pap IIID 1 (also called LSIL – low grade squamous intraepithelial lesion – in some countries), there are abnormal cells that indicate changes in the tissue: so-called dysplasia. However, these very often tend to regress. This finding is also called mild to moderate dysplasia and occurs relatively frequently in young women. The affected women are monitored using watchful waiting. If the findings have not changed after one year, further examinations such as a vaginal endoscopy (colposcopy) are necessary.
At Pap IV, there is a high probability of severe tissue changes (dysplasia), also called HSIL or high grade squamous intraepithelial lesion. The affected woman may have a precancerous stage or already have cervical cancer, and such mutations rarely disappear on their own. Regardless of the result of HPV tests, a biopsy provides clarity: in a vaginal endoscopy (colposcopy), a tissue sample is taken from the cervix. Since not every gynaecologist can perform a colposcopy, affected women may have to make an appointment at a so-called dysplasia consultation or a specialised gynaecological clinic.
In the case of a Pap V finding, malignant altered cells are detectable in the Pap smear. The probability of cervical cancer is very high. Nevertheless, Pap V is still not a cancer diagnosis. For a reliable result, a tissue sample via vaginal endoscopy (colposcopy) is necessary.
|Pap Group||Alternative name||Meaning||Examination||When is GynTect® useful?|
|Pap I||NILM||Unremarkable, normal findings||Next examination at the normal necessary examination interval for the early detection of cervical cancer|
|Pap II||ASC-US||Slightly abnormal, but not much changed||Depending on the patient’s medical history, the Pap test may be repeated||The GynTect® test can provide rapid certainty. Consult your gynaecologist!|
|Pap III||ASC-H (Pap III)|
LSIL (Pap IIID1)
HSIL (Pap IIID2)
|Unclear, inconclusive findings. There is dysplasia, but no cancer yet||Active monitoring (watchful waiting), and where appropriate, Colposcopy||The GynTect® test can provide rapid certainty. Consult your gynaecologist!|
|Pap IV||HSIL||A precancerous stage is likely, an existing cancer is also possible||Colposcopy-directed biopsy|
|Pap V||Cervical cancer||Malignant cell changes were found. Cervical cancer is very likely||A comprehensive cancer diagnosis is necessary. Colposcopy-directed biopsy|