GynTect®
GynTect® can provide patients with rapid certainty after abnormal findings are detected during a cytological examination such as a Pap smear. This molecular biological test detects cervical cancer and its preliminary stages in a rapid and reliable way, making GynTect® a good accompaniment to the watchful waiting strategy.
If the Pap smear is abnormal or the HPV test is positive following a cervical cancer screening, the patient can be put in a special situation. Although both tests indicate a potential cancer, in many cases there is no malignant disease present and the positive test result was a “false alarm”. Further examinations are necessary for definitive medical clarification, such as a colposcopy, with biopsy if necessary. In case of abnormalities, the allegedly affected tissue is often prematurely removed.
Persistent infection with HPV may lead to genetic instability within infected cells, and eventually cause cervical carcinoma. During carcinogenesis changes at the cellular DNA (methylations) occur.
With GynTect®, methylation changes at six different locations, which specifically occur during carcinogenesis, are detected within the DNA. Thus GynTect only detects patients with malignant changes.
If there is a positive GynTect® result, a malignant precursor or even cancer is very likely. Further steps such as diagnostics assisted by colposcopy and surgical therapies are recommended.
With a negative GynTect® result, a cancer diagnosis could be excluded at the time of testing. If there was an abnormal Pap test or HPV infection prior to the test, it is recommended to monitor them further in a watchful waiting strategy.
Precise results in just a few days
Based on available study data, GynTect® provides a clear indication of the malignancy status in patients with an abnormal Pap smear: In all previous studies, GynTect® was able to detect all cervical cancer cases (sensitivity = 100 %).
In cytologically inconspicuous patients, GynTect® is rarely positive (specificity = 96.6 %). Cancer develops via the histopathologically defined dysplasias CIN1, CIN2 and CIN3, for which the detection rate of GynTect® increases continuously. This indicates prognostic value of GynTect® cancer markers.
For some years now, we have been in close contact with the anti-cancer activist Myriam von M. She started her FUCK Cancer campaign in 2014 and has been an idol for cancer patients and their relatives ever since. People who belong to the risk group for cervical cancer have also turned to Myriam von M. on Facebook. She has reached out to women with abnormal findings to share their experiences.
When reading the submissions we noticed that many women felt insecure or even guilty after an invasive procedure. In particular, pregnant women or women who want to have children wonder if they have done everything possible to avoid miscarriage. GynTect is an option which can respond to a patient’s unique situation.
Here is a selection of the submissions:
‘In 2005, I had a conisation after abnormalities were found in the smear. Ten years later, I got pregnant. After the 7th month, funnelling developed and I had to be put on bed rest. My child was then born healthy. Nevertheless, after what I’ve experienced, I’m very afraid of a second pregnancy.’
‘During my pregnancy, I received a Pap III finding. In the 19th week of pregnancy, I underwent conisation. In the 25th week of pregnancy, I had a stillbirth because of a germ contamination. The doctors could not rule out that this was a consequence of conisation. I feel very guilty and at the same time I am afraid of getting cervical cancer.’
‘In 2010, my Pap test was positive in the 20th week of pregnancy. At that time, I refused conisation and was closely monitored. Six months after I gave birth, a conisation was performed. In 2015, I became pregnant again and miscarried.’
‘Since I was 25, I was Pap IIId and HPV positive. About two years later, I had my child. Afterwards, I had a conisation at my own request, so that I would not have to go for an examination every three months. Due to deteriorating values, further conisations followed. After that, I had a miscarriage. The question of whether I did something wrong or whether I could have done something to stop it from happening is always in my head!’
‘Two years after my conisation, I became pregnant. I had a very problematic pregnancy and was given bed rest after the 6th week of pregnancy. I should have visited a psychologist. That’s what I think in retrospect. I want another child, but I’m afraid I’ll have to be put on bed rest like that again.’
Order GynTect® or ScreenYu Gyn®
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Löbstedter Str. 41
07749 Jena
Germany
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Picture credits
Hero Header: Stock-Asso / Shutterstock.com
Patient: Stock-Asso / Shutterstock.com
Scheme of the GynTect® procedure: oncgnostics.com
Proposal for the implementation of GynTect® in the S3 guideline: oncgnostics GmbH
Study data for GynTect®: oncgnostics GmbH
